Cytochrome P450 (CYP) proteins are responsible ... is used to maintain the efficacy of a CYP3A4-metabolized drug, the unnecessary inhibition of other CYPs will lead to dangerously elevated plasma ...

Most drugs are metabolized by CYP3A enzymes ... Of particular importance are cytochrome P450 enzymes, heme-containing mono-oxygenases which catalyze the final step in the incorporation of oxygen ...