By examining pulse-labeled p53, it was revealed that the newly synthesized p53 undergoes rapid UI degradation by the 20S proteasome, and this degradation can be inhibited by Hdmx, the p53 nanny 16.

Unmodified Mdm2 is a substrate for polyubiquitination and subsequent degradation. Consequently, SUMOylation may be required for efficient degradation of p53 in the absence of DNA damage.

Background: Tobacco is considered the most important cause of lung cancer, but other factors could also be involved in its pathogenesis. The aim of the present work was to establish an association ...