The absence of Ptch activity can promote tumour initiation, and subsequent loss of p53 function seems to promote tumour-cell growth in a mouse model of medulloblastoma. Beachy and colleagues ...

p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...

Our collaborators at the Institut Curie, Paris and NCNP, Tokyo have shown that signalling through the non-receptor tyrosine kinase SRC is upregulated in Group 4 medulloblastoma and furthermore, that ...

A study published in Nature Genetics reveals new insights into how medulloblastoma, the most common malignant brain tumor of childhood, can arise as the cerebellum develops. Researchers discovered ...

Scientists at The Hospital for Sick Children (SickKids) have identified a key gene that could lead to next-generation treatments for medulloblastoma, the most common malignant brain tumor in children.