Advances in gene-editing technologies like CRISPR are opening doors to directly correct p53 mutations in cancer cells. Additionally, researchers are exploring combination therapies that pair p53 ...

Although there are tumor suppressor genes in normal cells to prevent cancer, gene mutations can cause a normal cell to become a cancerous one. Among those genes, TP53 (encoding the p53 protein ...

All the various tp53 and Trp53 clones used in cancer studies came from transformed cell lines; they all contained mutations. Once researchers redefined p53 as a tumor suppressor gene and generated ...

A comparison of patients with and without BRCA gene mutations receiving prophylactic risk-reduction surgery suggest ...

No one really understands why activation of the tumor suppressor p53 sometimes leads to cell-cycle arrest and sometimes induces an apoptotic program. It has been proposed that post-translational ...

Wojciech Jurczak, MD, PhD, discusses advancements in B-cell lymphoma therapy, focusing on immunotherapy, molecular-targeted agents, and more.

The aim of the present work was to establish an association between wood smoke exposure and lung cancer pathogenesis, and to analyze the effects of wood smoke on p53 and murine double minute 2 ...