14 In the excitement of discovery that sparked new explanations for cancer, scientists had quickly fit a label onto p53, but an oversight soon came to light. All the various tp53 and Trp53 clones used ...

A research team at the University of Konstanz, led by toxicologist Ivano Amelio, has demonstrated how differently individual mutations of the tumor suppressor p53 affect pancreatic carcinomas.

A comparison of patients with and without BRCA gene mutations receiving prophylactic risk-reduction surgery suggest ...

Still, cancer is not an inevitable consequence of mutation, but is kept in check by intrinsic tumor-suppressor programs ... Modeling the therapeutic efficacy of p53 restoration in tumors. Cell.

No one really understands why activation of the tumor suppressor p53 sometimes leads to cell-cycle arrest and sometimes induces an apoptotic program. It has been proposed that post-translational ...

Wojciech Jurczak, MD, PhD, discusses advancements in B-cell lymphoma therapy, focusing on immunotherapy, molecular-targeted agents, and more.

The aim of the present work was to establish an association between wood smoke exposure and lung cancer pathogenesis, and to analyze the effects of wood smoke on p53 and murine double minute 2 ...