Multiple components of the pathway are frequently targeted by amplification, mutation, and, less commonly, translocation in neoplasia; there is also crosstalk with the p53 and retinoblastoma ...

New research uncovers new insights into preventing chronic inflammation caused by aging-related zombie-like cells. In humans ...

Over the years, scientists have devised various strategies to target the p53 pathway, or the network of molecules p53 ...

为探究 CHI3L1 在结直肠癌（CRC）放疗抗性中的作用，研究发现其可促癌细胞增殖等，为治疗提供新思路。 在癌症治疗的广阔领域中，结直肠癌（Colorectal Cancer，CRC）一直是困扰全球医学界的难题。它作为常见的胃肠道恶性肿瘤，严重威胁着人类的健康。放疗，作为 CRC 综合治疗的重要一环，对于延长患者生存期、降低局部复发率起着关键作用，尤其是在直肠癌的治疗中，其地位更是不可替代。然而 ...

The researchers found that navtemadlin reached effective concentrations in the tumor and activated the p53 pathway, but the tumors eventually relapsed. The team then used tissue samples from three ...

ERG positivity, an early molecular alteration in prostate cancer development, exhibits differing prevalence between African American and White patients. Nevertheless, the extent of race-based ...

The aim of the present work was to establish an association between wood smoke exposure and lung cancer pathogenesis, and to analyze the effects of wood smoke on p53 and murine double minute 2 ...

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related mortality worldwide. Current treatment modalities are few or ...