By analyzing huge amounts of biological data, the use of machine learning accelerates the identification of critical control ...

Over the years, scientists have devised various strategies to target the p53 pathway, or the network of molecules p53 ...

New research uncovers new insights into preventing chronic inflammation caused by aging-related zombie-like cells. In humans ...

p53 and RB are at the heart of the two main tumour-suppressor pathways that control cellular responses to potentially oncogenic stimuli. Each pathway consists of several upstream regulators and ...

Multiple components of the pathway are frequently targeted by amplification, mutation, and, less commonly, translocation in neoplasia; there is also crosstalk with the p53 and retinoblastoma ...

As our bodies grow, cells proliferate to form tissues, and cells frequently have to be repaired or replaced throughout life..

New findings show that the mitochondria powering our cells also control the ability of a DNA repair protein to suppress the senescence-associated secretory phenotype (SASP), which causes zombie-like ...

The pre-IND meeting provided an opportunity for the Company to discuss its Investigational New Drug (IND) development plan and receive FDA guidance on nonclinical and clinical study requirements for ...

p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells - ...

The aim of the present work was to establish an association between wood smoke exposure and lung cancer pathogenesis, and to analyze the effects of wood smoke on p53 and murine double minute 2 ...