干扰素基因刺激因子（STING）通路在启动针对病原体和肿瘤的 免疫 反应中发挥着关键作用。STING 信号的激活对于多种癌症疗法的抗肿瘤效果至关重要，STING 激动剂在小鼠模型中治疗不同癌症方面展现出了令人瞩目的潜力。

为解决难治性卵巢癌免疫治疗效果不佳的问题，研究人员探究菊苣酸（CA）联合 PD-1/PD-L1 阻断剂的疗效，发现联合治疗或可有效治疗卵巢癌。 研究人员采用了多种关键技术方法。首先构建了患者来源的异种移植（PDX）模型，用化疗耐药的晚期 HGSC 患者的恶性腹水和外周血单个核细胞（PBMC）注入免疫缺陷的 NSG 小鼠，成功建立了免疫活性的 PBMC-PDX 模型。接着运用单细胞 RNA ...

Phase III DIPPER trial shows that adjuvant camrelizumab administered after induction-concurrent chemoradiotherapy ...

as well as animal models lacking PD-1 signaling. The researchers found that impaired or absent PD-1 activity can significantly reduce the diversity and quality of antibodies produced by memory B ...

In the arthritic environment, Treg cells exhibit altered metabolic activity, reduced suppressive function, and increased PD-1 ...