Pediatric high-grade gliomas, particularly H3K27M diffuse midline gliomas (DMG), are aggressive malignant brain tumors with a poor prognosis.

Pediatric high-grade gliomas, particularly H3K27M diffuse midline gliomas (DMG), are aggressive malignant brain tumors with a poor prognosis. Previous research suggests that platelet-derived growth ...

High-grade glioma, an aggressive form of pediatric and adult brain cancer, is challenging to treat given the tumor location, incidence of recurrence and difficulty for drugs to cross the blood-brain ...

Scientists performed a first-ever clinical test of the therapy avapritinib in pediatric patients with high-grade glioma. They ...

A new therapy offers hope for treating pediatric brain tumors, targeting cancer cells while minimizing side effects for young ...

An international team of clinical collaborators, led by physician scientists from Dana-Farber Cancer Institute, performed a ...

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The first part – which was approved in January – covered the use of the drug in GIST patients with a platelet-driven growth factor receptor alpha (PDGFRa) exon 18 mutation, including PDGFRA ...

“In contrast, patients with non-KIT exon 11 mutations and wild-type KIT/PDGFRA GISTs exhibited less favorable responses to [Gleevec], suggesting that in these cases, the transition to surgery should ...

High-grade glioma, a difficult-to-treat and aggressive form of pediatric and adult brain cancer, responded to FDA-approved avapritinib. | Drug Discovery And Development ...

Previous research suggests that platelet-derived growth factor receptor alpha (PDGFRA) appears to play a multifaceted role in the pathogenesis of both adult and pediatric high-grade gliomas.