PI3K/AKT 信号通路激活后，会作用于多个下游靶点，其中 mTOR（哺乳动物雷帕霉素靶蛋白，Mammalian target of rapamycin）是一个关键靶点。mTOR 被 PI3K/Akt 信号通路激活后，对心脏具有重要的保护作用，能够抵御缺血再灌注带来的损伤。在心脏缺血再灌注的过程中 ...

Inhibitors that target key components of this pathway, including PI3K, AKT and mammalian target of rapamycin (mTOR), are being actively developed. Some of them have reached clinical trials in ...

PI3K-Akt-mTOR通路作为细胞内重要的信号转导途径，不仅在细胞的凋亡、存活、增殖及血管生成等过程中发挥重要的生物学功能，还介导了肿瘤、糖尿病等诸多疾病的病理过程，故成为信号转导研究者、疾病病理研究者及药物研发者关注的焦点。 为感谢广大用户对 ...

This figure illustrates the major signaling pathways and their intricate crosstalk in BC, focusing on the GPCR, RTKs, RAS/RAF/MEK1/2/ERK1/2, MAPK, HER2, PI3K/Akt/mTOR, Wnt/β-catenin, NF-κB ...

The biomarker analysis found patients with certain mutations in the PI3K/AKT/mTOR pathway and MAPK pathway may be resistant to Truqap.

Our laboratory is dedicated to understanding the consequences of activation of these pathways and to using this information to develop mechanism-based therapeutic strategies. The laboratory is ...

The authors discuss several major pathways involved in breast cancer, including PI3K/Akt/mTOR, RAS/RAF/MEK/ERK, HER2, Wnt/β-catenin, Notch, NF-κB, and the DNA damage response (DDR). These ...

Signaling in the PI3K/AKT/mTOR pathway is often disrupted in cancers, including ovarian cancer, Herzog noted in his introduction. In particular, key downstream pathways are mediated by AKT.