p110 autophosphorylation and phosphorylation of p85 downregulate activity of the complex. Two chemical inhibitors have been used to probe the function of PI3K: wortmannin, a fungal metabolite that ...

为解决糖尿病伤口愈合困难的问题，解放军总医院的研究人员开展了关于 NETs 对糖尿病伤口愈合影响的研究。结果发现 NETs 经 PI3K/Rac1 通路影响巨噬细胞吞噬功能，阻碍伤口愈合。该研究为治疗提供新策略，值得科研读者一读。 在当今社会，随着生活水平的提高 ...

Phagocytosis is a fundamental mechanism used by the body to resist pathogens and restore physiological homeostasis. Herein, to identify small molecules with anti-inflammatory properties via ...

The PIK3CA gene, which encodes the p110α subunit of phosphoinositide 3-kinase (PI3K), is among the most frequently mutated oncogenes in cancer. These mutations drive tumor progression ...