During development, cells grow, expand, and migrate to generate tissues and organs in a highly controlled manner. Many ...

It is likely that PI3K inhibitors will need to be used in combination with other drugs that induce cell stress, such as other signaling inhibitors, radio- and chemotherapy. Points at which ...

为解决乳腺癌 PI3K 抑制剂耐药问题，研究人员开展相关研究，发现耐药细胞对代谢药物敏感，或可用于临床治疗。 在全球范围内，乳腺癌是女性中最常见的癌症，也是癌症相关死亡的主要原因之一。根据激素受体（HR）和人表皮生长因子受体 2（Her2）的状态 ...

A new study on the genetic causes of the PTEN Hamartoma Tumour Syndrome (PHTS) has found that inhibitors of the PI3ka pathway, commonly used as anticancer drugs, are also effective against this ...

Verastem Oncology (Nasdaq: VSTM), a biopharmaceutical company committed to advancing new medicines for patients with RAS/MAPK ...

Seth Wander, MD, PhD, discusses genomic variations effect on elacestrant in ESR1-mutated breast cancer from findings in real-world data.

Cellular reprogramming is an intrinsic evolutionary trait to constantly promote adaptations that confer survival advantage.

Some people taking BTK inhibitors have developed skin cancer or other cancers. Doctors recommend protecting your skin while on these medications to lower this risk. PI3K is another protein ...