为探究 IER5 的细胞功能及作用机制，研究人员开展了 IER5 对 PP2A/B55α 磷酸酶作用的研究。结果发现 IER5 是 PP2A/B55α 的核内抑制剂，明确了结合位点和抑制机制，还发现类似蛋白也存在相似作用，为调控 PP2A/B55α 提供理论基础。 IER5 是 AP1 调控的即刻早期反应（IER ...

编辑推荐：针对丝氨酸/苏氨酸磷酸酶缺乏特异性抑制剂的难题，Lindsey A. Allan团队开发了"directSLiMs"系统，通过药物诱导的SLiM肽 ...

Dual checkpoint inhibitors led to longer overall survival in patients with high-risk endometrial cancer who displayed ...

A groundbreaking study published in Research (2025, DOI: 10.34133/research.0545) has elucidated the molecular mechanisms by which protein phosphatase 2A (PP2A) regulates CD8+ T cell-mediated immune ...