PSEN1 encodes presenilin-1, a subunit of γ-secretase, the aspartyl protease responsible for Aβ generation. More than 300 mutations in PSEN1 have been reported and mutations in PSEN1 are the most ...

The following genes that make up the gamma-secretase complex may develop mutations that can increase your risk of developing HS: Nicastrin (NCSTN) Presenilin 1 (PSEN1) Presenilin enhancer 2 ...