研究人员们巧妙地利用荧光共振能量转移原理，将PTEN蛋白改造为构象敏感的"分子探针"。通过在其N端和C端分别标记绿色荧光蛋白与淬灭蛋白 ...

在微观的细胞宇宙中，一个名为PTEN（Phosphatase and tensin homolog）的蛋白质如同精密的分子刹车，时刻调控着细胞增殖与存亡。这个仅有403个氨基酸的 ...

Mutations in PIK3CA and loss of PTEN contribute to its hyperactivation. The Wnt/β-catenin pathway promotes EMT and metastasis, driven by Wnt signaling through LRP5/6 and β-catenin, which ...

A new review was published in , Volume 16, on March 13, 2025, titled "Signaling pathway dysregulation in breast cancer." ...

Innovations in therapeutic strategies, coupled with a deeper understanding of breast cancer biology, will be essential for advancing personalized ...

"ERBB2 and PTEN are a part of different signaling pathways, but we believe they have a correlation in endometrial cancer," Dunston said. "The effect of ERBB2 targeting on endometrial cancer with ...