Since its introduction by Bert Sakmann and Erwin Neher in 1978, patch-clamping techniques have become widely accessible with commercially available equipment. And while the science of patch clamping ...

Tangentially, other biophysicists tried to figure out their own early version of the patch clamp method. David Clapham, now a biophysicist at the Howard Hughes Medical Institute, became fascinated ...

In contrast, a patch-clamp electrode, the gold standard in neuronal recording, can effectively get inside an individual neuron to record a faint synaptic signal with high sensitivity, and thus can ...