Related: Tiny Calico Kitten Turned Stunning Queen Is Magazine Cover Material. Another person added, "Don’t think I’ve ever seen a male Calico! So handsome." Someone else respo ...

involving multiple genes that control color distribution and pattern formation. The calico cat aspect (tri-color orange, black, and white patches) comes from X-chromosome inactivation, known as ...

Such a pattern results from a genetic process known as piebalding, whereby patches of colored fur possess white, unpigmented patches. Calico cats represent an enchanting mixture of orange ...