In the periphery, TRPV1 is activated by exposure to noxious heat and protons and is responsible for peripheral heat hyperalgesia. Central sensitization is a major problem in pain conditions across ...

Hyperalgesia takes your pain and makes ... In some conditions, research suggests allodynia may be caused by peripheral sensitization, which involves the nerves outside of your central nervous ...

2 A drug that induces peripheral sensitization of somatic or sympathetic nerves and/or central sensitization of brain systems could potentiate the pathophysiological mechanisms that contribute to ...