Bortezomib (a proteasome inhibitor) has recently been approved for treatment of relapsed multiple myeloma, a plasma cell neoplasia, owing to the sensitivity of immunoglobulin-synthesizing myeloma ...

Cells maintain a continuous free pool of ubiquitin that can be conjugated onto target proteins to mark them for degradation by the proteasome. Now, in Cell, Finley and colleagues show that the ...

Researchers from the Weizmann Institute of Science have discovered that structural fragments of human cells — proteasomes are capable of producing natural antibiotics from parts of damaged proteins.

Multiple myeloma (MM) is a malignant plasma cell disorder accounting for approximately ... immunomodulatory drugs (IMiDs) and the proteasome inhibitor bortezomib. [1] IMiDs are structural and ...

plasma, cell lysates and tissue homogenates Offered through the Standard BioTools™ CAP/CLIA-accredited laboratory in Boulder, Colo. Single SOMAmer Reagents: a powerful antibody alternative for ...