Its exact mechanism of action is unknown. Pregabalin is rapidly absorbed and exhibits linear pharmacokinetics after oral administration. The lack of hepatic metabolism and lack of interaction with ...

Pregabalin 82.5mg, 165mg, 330mg; ext-rel tabs. Pregabalin binds with high affinity to the alpha2-delta site (an auxiliary subunit of voltage-gated calcium channels) in central nervous system tissues.

As pregabalin and gabapentin have a similar mechanism of action, it is not expected that pregabalin would benefit a patient when used concomitantly with gabapentin; however, these drugs could be ...