Hepatic synthesis of bile acids is the primary pathway for cholesterol catabolism. The cholesterol 7α-hydroxylase enzyme (encoded by CYP7A1) represents the rate-limiting step of the multi ...

The research teams led by Kristina Schoonjans and Rizlan Bernier-Latmani at EPFL, have identified Clostridium scindens, a bacterium that converts primary bile acids into 7α-dehydroxylated bile ...

However, a recent randomized, controlled trial has surprisingly shown that the use of high-dose UDCA in patients with primary sclerosing ... write off the use of bile acids as a potential therapy ...

is a chemically modified bile acid that has already shown promising results in the treatment of liver diseases such as primary sclerosing cholangitis (PSC) and is being tested in clinical studies.

is a chemically modified bile acid that has already shown promising results in the treatment of liver diseases such as primary sclerosing cholangitis (PSC) and is being tested in clinical studies.

is a chemically modified bile acid that has already shown promising results in the treatment of liver diseases such as primary sclerosing cholangitis (PSC) and is being tested in clinical studies.

Amino acids such as glycine and taurine play a crucial role in liver and bile function. Glycine, a primary component of bile, ...