Glioblastoma (GBM), one of the most aggressive types of brain cancer, is one of the greatest challenges for medicine, both ...

Almost two decades have passed since Stanley Prusiner proposed that the transmissible agent causing spongiform encephalopathies consists of a misfolded protein — but the biology of prion ...

为了了解朊病毒在癌症生物学中的重要性，首先需要了解GBM的作用机制。正如Lopes所解释的那样，手术和替莫唑胺治疗会杀死快速增殖并形成肿瘤“团块”的细胞。然而，所谓的肿瘤干细胞（胶质母细胞瘤干细胞）在脑组织中仍然处于休眠状态。当它们再次活跃时，它们能够再次协调肿瘤生长。

A silent but deadly epidemic is creeping through North America and scientists are sounding the alarm.

An autopsy had revealed the cause to be prion disease, in which the prion protein, the normal function of which is unclear, changes form and spontaneously clumps together and causes the brain to die.

also called Creutzfeldt-Jakob disease (CJD), results from the misfolding of a normal prion protein—an essential protein present in everyone. The misfolded form of the protein, the cause of CJD ...

Instead of mining protein biomarkers showing differential expression simply based on the comparison of control and prion-infected sample, other efforts have been made to identify prion disease ...

Clumps of killer rogue prion proteins form in the brain, and make holes, causing it to look like a sponge. At the time, scientists knew about a sheep disease called scrapie that damaged the brain ...

The algorithm was tested on proteins containing both disordered and non-disordered regions, including TDP-43 (associated with ALS), ataxin-3 (linked to Machado-Joseph disease), and the prion ...