Glioblastoma (GBM), one of the most aggressive types of brain cancer, is one of the greatest challenges for medicine, both ...

为了了解朊病毒在癌症生物学中的重要性，首先需要了解GBM的作用机制。正如Lopes所解释的那样，手术和替莫唑胺治疗会杀死快速增殖并形成肿瘤“团块”的细胞。然而，所谓的肿瘤干细胞（胶质母细胞瘤干细胞）在脑组织中仍然处于休眠状态。当它们再次活跃时，它们能够再次协调肿瘤生长。

Accumulation of a protein called TDP-43 is a key feature of ALS and frontotemporal dementia. In a newly published study, ...

Dysfunctional Family. A family tree of tau folds now incorporates two new structures—P301L, P301T (bottom)—and fills in ...

A silent but deadly epidemic is creeping through North America and scientists are sounding the alarm.

also called Creutzfeldt-Jakob disease (CJD), results from the misfolding of a normal prion protein—an essential protein present in everyone. The misfolded form of the protein, the cause of CJD ...

By singling out a protein they say is involved in the growth of glioblastoma, scientists say they can create targeted ...

Director Kelly Susewind has made decisions on proposed rules designed to limit the spread of chronic wasting disease (CWD) in Washington.

The algorithm was tested on proteins containing both disordered and non-disordered regions, including TDP-43 (associated with ALS), ataxin-3 (linked to Machado-Joseph disease), and the prion ...

Led by a team at the Broad Institute, the new gene therapy aims to address the root cause of prion disease by using the CHARM (Coupled Histone tail for Autoinhibition Release of Methyltransferase) ...