Prof. Si Longlong's team from the Shenzhen Institutes of Advanced Technology of the Chinese Academy of Sciences constructed a ...

The proteasome is a microscopic barrel-shaped machine found in every cell of the human body. For decades, scientists only knew it for breaking down old or damaged proteins into fragments so their ...

Following promising phase 1 data, ISB 2001 has gained fast track designation from the FDA for the treatment of ...

Mutations in the oncogene KRAS are widespread in several human cancers, including pancreatic ductal adenocarcinomas (92%), colorectal carcinomas (49%) and lung adenocarcinomas (35%). These mutations ...

Tobacco-based products, including e-cigarettes, have gained popularity as perceived safer alternatives to traditional smoking despite their addictive nature. However, emerging evidence shows that ...

Despite advancements in melanoma therapy, the prognosis remains unfavorable for many patients. The proteasome inhibitor MG132 has shown therapeutic potential through pathway regulation, yet its ...

The introduction of new agents immunomodulatory drugs (IMiDs) and proteasome inhibitors has brought a major shift in therapeutic paradigm in the treatment of newly diagnosed and refractory ...

Researchers determined short-term blood pressure variability is an independent predictor of CTR-CVT in patients with multiple myeloma undergoing treatment with proteasome inhibitors.

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