Amyloids can be broadly defined as insoluble protein aggregates containing a characteristic highly ordered, β-sheet-rich structural motif. The latter can be identified histologically with dyes ...

Neurodegenerative diseases like Huntington’s disease pose significant challenges to modern medicine. Recent research has ...

A central challenge in DSP is product stability, as biopharmaceutical proteins can be highly sensitive to environmental stresses, causing protein aggregation, reduced therapeutic efficacy and ...

Why do problems occur with a special variant of 'protein glues', the split inteins, that severely limit their use in producing proteins? A team has now answered this question.

A new study suggests that targeting the protein alpha-synuclein could be a possible new target for treating melanoma.

Proteins are the building blocks of life. They consist of folded peptide chains, which in turn are made up of a series of ...

The clumping together of misfolded proteins is known as protein aggregation. In several neurodegenerative diseases, including ...

为解决现有蛋白聚集标记物的局限性问题，研究人员开展了关于真核细胞质蛋白聚集新型报告基因 iPAR（inducible Protein Aggregation Reporter）的研究。结果显示 iPAR 可定量研究胞质聚集体动力学等，为研究相关疾病提供新可能，推动了蛋白聚集研究的发展。 在细胞的微观世界里，蛋白质就像一群忙碌的 “小工匠”，有条不紊地执行着各种任务，维持细胞的正常运转。然而，当细胞 ...

The findings provide further evidence for a prion-like paradigm wherein protein aggregation occurs in a templated fashion. This breakthrough provides the research field with a powerful way to model ...

In general, mutations causing inherited forms of the respective diseases affect the folding, aggregation and/or solubility of these proteins. In Alzheimer's disease (AD), amyloid β-protein (Aβ ...

A refined lab test for measuring protein aggregates in neurodegenerative diseases like Parkinson's has been developed, potentially enhancing diagnosis and drug development.

A small protein involved in neurodegeneration leading to Parkinson's disease also drives a type of skin cancer known as melanoma, according to new research.