A novel artificial intelligence (AI) tool has revealed how disease-linked proteins misfold into harmful structures, a key ...

A novel artificial intelligence (AI) tool has revealed how disease-linked proteins misfold into harmful structures, a key advance in understanding neurodegenerative disorders such as Alzheimer's and ...

Amyloids can be broadly defined as insoluble protein aggregates containing a characteristic highly ordered, β-sheet-rich structural motif. The latter can be identified histologically with dyes ...

A central challenge in DSP is product stability, as biopharmaceutical proteins can be highly sensitive to environmental stresses, causing protein aggregation, reduced therapeutic efficacy and ...

Neurodegenerative diseases like Huntington’s disease pose significant challenges to modern medicine. Recent research has ...

Why do problems occur with a special variant of 'protein glues', the split inteins, that severely limit their use in producing proteins? A team has now answered this question.

Misfolded proteins (also called toxic conformations) are typically insoluble, and they tend to form long linear or fibrillar aggregates known as amyloid deposits. But how can a protein change so ...

Parkinson's disease (PD) and Lewy body dementia (LBD) are incurable and progressive neurodegenerative disorders, with some ...

The findings provide further evidence for a prion-like paradigm wherein protein aggregation occurs in a templated fashion. This breakthrough provides the research field with a powerful way to model ...

A new study suggests that targeting the protein alpha-synuclein could be a possible new target for treating melanoma.

To overcome these limitations, scientists developed the real-time quaking-induced conversion (RT-QuIC) assay for both research and diagnostic use, where prion seeds taken from specimens induce protein ...

Get Instant Summarized Text (Gist) A refined lab test for measuring protein aggregates in neurodegenerative diseases like Parkinson's has been developed, potentially enhancing diagnosis and drug ...