The demonstration that the native state of a long lived protease is less stable than a partially folded 'molten globule' like state shatters long standing preconceptions about protein folding.

deviations from a perfectly funneled landscape that otherwise guides the folding, called local frustration, are essential for ...

“Eliminating unlikely structures that have, for instance, hydrophobic residues exposed to solvent, the program intelligently samples the total protein-folding landscape, testing perhaps a million or ...

We are interested in elucidating how changes in the protein folding landscape contribute to phenotypic heterogeneity during aging, how these changes contribute to the aging process itself, and how ...

Artificial intelligence (AI) is reshaping the scientific landscape, offering fantastic ... which has solved the long-standing mystery of protein folding. Alongside emerging innovations like ...

Shortly after AlphaGo’s success in 2016, DeepMind aimed to tackle the next challenge: protein folding. Hassabis’ and Jumper’s team won that year’s CASP, and AlphaFold1 left quite an impression for ...

The scientists believe that the current research landscape in the field of computational ... sequences that do not disrupt the folding of proteins. However, they struggle when it comes to ...