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Cell line development typically includes the screening of thousands of clones in an effort to find the few that are stable, grow as expected, and produce high product yields. The time it takes from ...
However, glycosylation has traditionally been notoriously difficult to study. Only a small portion of proteins in the cell ..
and N-glycosylation remain attached to the protein backbones, allowing determination of the site and identity of PTMs. Alan Marshall, professor and director of the Ion Cyclotron Resonance Program ...
O-fucosylation, a type of protein glycosylation, uniquely occurs on specific protein domains, including the EGF domain in Notch. FUT10 and FUT11, enigmatic fucosyltransferases with weak or unknown ...
However, glycosylation has traditionally been notoriously difficult to study. Only a small portion of proteins in the cell ..