In principle, this can be assessed by measuring the distinctive firing patterns, known as complex spikes, generated by Purkinje cells — the neurons that generate the output of the cerebellum.

This regulation keeps glycolysis, the process by which cells convert glucose into energy, in Purkinje cells low, thereby ...

My experimental work also looks at history dependence but from the point of intrinsic excitability in cells. In this case, we combine electrophysiology, multi-photon imaging, and biophysical modeling ...

Cerebellar ataxia, a hallmark of cerebellar degeneration (CBND), is driven by mitochondrial dysfunction in Purkinje cells. In this study, transplanting mitochondria into CBND mice improve ...