Patients with generalized pustular psoriasis (GPP) experience frequent flares, and treatment alterations of off-label agents ...

Generalized pustular psoriasis may be caused or triggered by various factors, including genetic mutations, infections, and certain medications. Generalized pustular psoriasis (GPP) is a severe ...

The pustular form of psoriasis has also been linked to specific mutations in the interleukin 36 receptor antagonist IL36RN gene. Abnormal growth of skin cells or keratinocytes and immune system ...

Patients with generalized pustular psoriasis continued to experience frequent ... “[Flares are] often accompanied by leukocytosis, skin pain, itching, scaling, burning and high fever,” Jamie ...

German drugmaker Boehringer Ingelheim has its first regulatory approval for spesolimab, its antibody therapy for rare and life-threatening skin disorder generalised pustular psoriasis (GPP), in ...

Boehringer Ingelheim's spesolimab has shown encouraging efficacy in a phase 2 trial in generalised pustular psoriasis (GPP), a rare and life-threatening skin disorder. GPP is very different from ...

are recruited to the skin by the above chemokines, attach by upregulated adhesion molecules at the inflammation site, and accumulate intraepidermally to form pustules. These findings explain why ...

Unlike other types of psoriasis, GPP involves severe bouts of systemic (body-wide) inflammation that causes painful, sterile pustules over large areas of inflamed skin. The condition can also lead ...