Generalized pustular psoriasis may be caused or triggered by various factors, including genetic mutations, infections, and certain medications. Generalized pustular psoriasis (GPP) is a severe ...

Unlike other types of psoriasis, GPP involves severe bouts of systemic (body-wide) inflammation that causes painful, sterile pustules over large areas of inflamed skin. The condition can also lead ...

The pustular form of psoriasis has also been linked to specific mutations in the interleukin 36 receptor antagonist IL36RN gene. Abnormal growth of skin cells or keratinocytes and immune system ...

are consistent with porcine juvenile pustular psoriaform dermatitis (PJPPD) 1. Figure 2: Photomicrographs of adjacent sections of haired skin over a lesion from the pig in Figure 1, stained with ...

The psoriasis pipeline possesses some drugs in mid- and late-stage development to be approved in the near future. The emerging landscape holds a dive ...

More information: Jamie L.W. Rhoads et al, Real-world clinical characteristics and treatment patterns of generalized pustular psoriasis flares, Journal of the American Academy of Dermatology (2025 ...

Pustular psoriasis is characterized by white or yellow, pus-filled, painful pustules surrounded by red skin. The pus isn’t ...

Patients with generalized pustular psoriasis continued to experience frequent ... “[Flares are] often accompanied by leukocytosis, skin pain, itching, scaling, burning and high fever,” Jamie ...

German drugmaker Boehringer Ingelheim has its first regulatory approval for spesolimab, its antibody therapy for rare and life-threatening skin disorder generalised pustular psoriasis (GPP), in ...

Boehringer Ingelheim's spesolimab has shown encouraging efficacy in a phase 2 trial in generalised pustular psoriasis (GPP), a rare and life-threatening skin disorder. GPP is very different from ...

are recruited to the skin by the above chemokines, attach by upregulated adhesion molecules at the inflammation site, and accumulate intraepidermally to form pustules. These findings explain why ...