Binding of both the RNA-binding protein TDP-43 and the m6A RNA modification chemical tag has been found to be altered in genes that are dysregulated in HD. Further, TDP-43 pathology, classically ...

More information: Yoshiki Ochiai et al, SUPREM: an engineered non-site-specific m6A RNA methyltransferase with highly improved efficiency, Nucleic Acids Research (2024). DOI: 10.1093/nar/gkae887 ...

N6-methyladenosine (m6A) is one such mechanism, where methyl groups are added to the N6 position of adenosine on RNA. Adding these methyl groups enhances RNA stability; however, their removal by ...

A new review article highlights the transformative role of circular RNA (circRNA) in cancer, revealing its potential as both a key player in tumor ...

N6-methyladenosine (m6A) is one such mechanism, where methyl groups are added to the N6 position of adenosine on RNA. Adding these methyl groups enhances RNA stability; however, their removal by ...

A new review article highlights the transformative role of circular RNA (circRNA) in cancer, revealing its potential as both a key player in tumor biology and a promising avenue for future therapies.

Here, Guang et al used CRISPR-edited stem cells to reveal that an obesogenic FTO SNP accelerates both muscle development and aging, by increasing RNA m6A demethylation. Here, the authors present ...

study hypothesis states that the pathological features of IHD are mirrored in circulating cellular or extracellular epitranscriptomes. The study focuses on m6A modifications as well as A-to-I editing ...

ICMR-NIV director discusses India's expanding VRDL network, vaccine manufacturing, viral disease surveillance, and One Health ...