Cancers driven by hiccups in RNA processing can’t hide from our immune system, according to new work published today in Cell. A cross-institutional team Fred Hutch Cancer Center and Memorial Sloan ...

Learn how single-cell transcriptomics is helping researchers explore gene activity and immune system diseases with ...

What's the difference between mRNA and pre-mRNA? It's all about splicing of introns. See how one RNA sequence can exist in nearly 40,000 different forms. Next, the snRNPs U2 and U4/U6 appear to ...

New research published in Molecular Neurodegeneration has revealed that mutations in three genes known to cause familial ...

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who carry mutations in splicing factor 3B subunit 1 (SF3B1) by Eisai's H3 Biomedicine subsidiary. RNA splicing occurs when a precursor form of mRNA – which is used as a template for protein ...

They can also be within the exon.” RBP splicing factors are sequence-specific, binding to their cognate sequence motifs like a lock and key. “Because the binding pocket of the RBP matches the sequence ...

The realization that most human genes generate multiple mRNAs encoding divergent protein isoforms via alternative splicing and polyadenylation has revealed extensive regulation that remains to be ...

When they studied the effect of this depletion on splicing patterns using RNA sequencing, they found that splicing was significantly affected in cell lines with cohesin mutations compared to controls.

DDX1, it turned out, is necessary for splicing transfer RNA (tRNA) molecules ... previous studies have shown that mutations that impair ribosome formation can also lead to similar defects.