来自新加坡国立大学的张阳教授团队提出了一种基于深度学习的高精度 RNA 结构预测框架 DRfold2，集成了预训练的 RNA 复合语言模型和去噪结构模块，用于端到端的 RNA 结构预测，其在多个基准测试中，相较于其他最先进的方法表现出色。

“RNA有很多家族，此前在解析RNA结构时，科研人员往往不确定应该选择哪些序列进行解析。”复旦大学智能复杂体系实验室研究员、文章共同通讯作者孙思琦解释道， “这就像开‘盲盒’，我们只能猜测哪些家族的序列可能具有稳定的结构。” ...

Unfortunately, only a small fraction of RNA structures have been determined experimentally, and the process of uncovering these structures requires significant time and effort. Using this time ...

Unfortunately, only a small fraction of RNA structures have been determined experimentally, and the process of uncovering these structures requires significant time and effort. Using this time ...

RNA has recently gained attention as a promising drug target. Unfortunately, only a small fraction of RNA structures have been determined experimentally, and the process of uncovering these structures ...

Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...

Dr. Kerstin Göpfrich at the Center for Molecular Biology of Heidelberg University has cleared a crucial hurdle. Using the new ...

A research team led by Rice University’s Yang Gao has uncovered new insights into the molecular mechanisms of ADAR1, a ...

A research team led by Rice University's Yang Gao has uncovered new insights into the molecular mechanisms of ADAR1, a ...