Recent structures of the Runx1–CBFβ heterodimer bound to DNA brings to six the number of characterized eukaryotic transcription factor families that use an immunoglobulin (Ig) fold to bind to DNA.

The drugs targeting FLT3 rewire the cell, resulting in the upregulation of other signaling pathway associated genes, which then restored AP-1 and RUNX1 binding. Drugging RAS, which is a key ...