We therefore used a reconstituted cell-free NADPH oxidase system to examine the role of Rac2 in the electron-transfer reactions necessary for the generation of superoxide anion. We show that Rac2 ...

Two papers published in Immunity describe a crucial role for the RAP and RAC2 GTPases in this process. Formation of the cSMAC is accompanied by the clustering of LFA1 molecules, which after ...