Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...

This historical perspective integrates 50 years of research on SOS mutagenesis in Escherichia coli with the proverbial '3R' functions—replication, repair and recombination—that feature DNA ...

However, since ssDNA is a common intermediate of DNA replication, recombination and repair, this capacity is essential, if for no other reason, than to protect the ssDNA from further untargeted ...

The team showed that blocking homologous recombination changed the way the ... radiotherapy depends on the engagement of ...

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The gene's interaction with RAD51 and PARP1 proteins is vital for DNA repair. PARP inhibitors, used in BRCA2-deficient cancer treatment, trap PARP1, destabilizing repair complexes.