Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...

Despite this extensive DNA repair, recombination is not overtly mutagenic; fine mapping of recombination products has shown that the exchange points of COs within a mammalian hot spot are precise ...

Results of a study led by the Vall d'Hebron Institute of Oncology (VHIO) support the feasibility of using RAD51 testing to ...

Published in Cell Reports Medicine, results of a VHIO-led study support the feasibility of using RAD51 testing to complement ...

DSBs arise from agents, such as ionizing radiation, and can also occur spontaneously during DNA replication. Our emphasis is on repair of DSBs by homologous recombination, with a particular interest ...

In contrast cohesin phosphorylation appears to primarily impact DNA repair speed. Here the authors reveal that in addition to promoting class switch recombination via inhibition of DNA end ...

The team showed that blocking homologous recombination changed the way the ... radiotherapy depends on the engagement of specific DNA repair pathways, particularly when radiation is given at ...

Sydney: Australian researchers have found that DNA repair may determine how cancer ... was repaired by a method called homologous recombination, they found that cancer cells died during ...

When cancer cells repair their radiotherapy-damaged DNA using "homologous recombination," they die during cell division. This type of death goes unnoticed by the immune system, limiting the ...

Published in Cell Reports Medicine, results of a VHIO-led study support the feasibility of using RAD51 testing to complement next-generation ...

The team showed that blocking homologous recombination changed the way the ... radiotherapy depends on the engagement of specific DNA repair pathways, particularly when radiation is given at ...