In mice, chronic exposure to inhaled hypoxia can normalize tissue hyperoxia and has been shown to extend lifespan in a mouse model of Leigh syndrome. Phase I clinical trials have demonstrated the ...

Tumour hypoxia has been pursued as a cancer drug target for over 30 years, most notably using bioreductive (hypoxia-activated) prodrugs that target antineoplastic agents to low-oxygen tumour ...

“By reversing hypoxia, IMGS-101 may restore T-cell access to tumours, enhancing the effectiveness of checkpoint inhibitors ...