Scientists use the term "stalled forks" for areas of replication forks where DNA polymerization is halted. Stalled forks activate ATR, which in turn phospohorylates its downstream target ...

which encompasses conditions that impede the normal progression of replication forks, and which is a major driver of cancer-associated genome instability. Through this approach, we aim to understand ...

Our lab showed that an analogous cohesion process occurs in bacteria, in which replicated DNA is linked together as it exits the replication fork, remaining stably attached for 10-20 minutes before ...

Research in my laboratory centers on: (i) the events that occur when the replisome (the multi-component enzyme machine that replicates chromosomal DNA) encounters blockages to replication fork ...

Researchers also discovered that two helicases cooperate to form "replication forks," ensuring simultaneous copying of both strands. The study shows this process is universal, from viruses to humans.