为改善肾透明细胞癌（ccRCC）患者预后，研究人员构建 RHO-GTPase 基因风险模型，成果意义重大。 肾透明细胞癌（clear cell renal cell carcinoma，ccRCC）作为肾癌中最常见的亚型，一直是医学界的 “硬骨头”。它就像一个隐藏在身体里的 “狡猾敌人”，预后状况常常 ...

Figure 1: In Drosophila development, the Rho GTPase mediates signalling pathways that direct several distinct morphogenetic processes. By injecting a dominant-negative form of XRhoA into embryos ...

The findings also support less studied pathways involved in the pathogenesis ... The role of ITSN1, Intersectin-1, is to activate CDC42, a small Rho GTPase involved in the growth and maintenance ...