Rho inhibition. Y27632, a selective Rho kinase (ROCK) inhibitor (Tocris, Ellisville, MO) was added to cells at a concentration of 20 μM/mL, 1 h before stretch and maintained throughout the ...

First, like Ras, Rho family proteins serve as guanine nucleotide-regulated binary switches that control signaling pathways that in turn regulate diverse cellular processes. Rho family proteins are ...