Numerous motor and structural proteins compose a highly ordered structure known as the sarcomere, the basic unit of muscle contraction in heart and skeletal muscles. Sarcomeric myosin heavy chain ...

Cardiomyopathy is a disease in which heart muscle is typically weakened or distorted ... corrects MyBP-C protein levels/expression in the sarcomere and dysfunctional contraction, while in vivo ...

These conditions are caused by genetic variants in sarcomeric proteins, which are essential for heart muscle contraction ... a key protein in the cardiac sarcomere. For instance, drugs like ...