However, these activated receptors also signal from endosome membranes, where they can physically interact with some of their downstream signaling factors. In animals, researchers first realized ...

It plays a key role in nutrient absorption, immune defense, signal transmission ... which plays a vital role in regulating endosome maturation. This gene encodes a deubiquitinating enzyme that ...

Ubiquitylation is the best characterised signal for entry into this pathway ... which are enriched in early endosome membranes. ESCRT-I is built around a heterotrimeric core to which flexibly ...

Recent work in The EMBO Journal describes a new hybrid post-translational modification of proteins, composed of a poly-ubiquitin chain that is attached to a target protein via a mono-ADP-ribose (MAR) ...