值得注意的是，该研究注意到FGFBP2+ NK细胞不仅在接受免疫治疗联合化疗的响应者中富集，还在仅接受新辅助化疗的响应者中富集。此外，FGFBP2+ NK样T细胞表现为高度克隆扩增的状态，且不表达PDCD1基因，提示了FGFBP2+ NK细胞可能通过不同于经典CD8+ T细胞的方式对肿瘤进行杀伤。体外实验观察到NK细胞能够杀伤化疗处理后进入压力状态的恶性肿瘤细胞系，提示了FGFBP2+ ...

A team of scientists from BGI-Research at Southern University of Science and Technology in Wuhan, Hubei province, and other ...

综上所述，该研究成功解析了肿瘤脑转移特征，并刻画了肿瘤从原发灶到脑转移进程的演化规律。该研究不仅为理解脑转移机制提供了关键资源，更鉴定出多个脑转移关键进展标志事件，提供了潜在治疗干预靶点，为改善脑转移患者临床疗效开辟了数据驱动研究的新范式。这一突破性成果有望推动 肿瘤转移 领域 精准 治疗策略的开发。

近日，郑州大学第一附属医院张毅教授团队联合北京大学生物医学前沿创新中心张泽民院士等合作团队，在国际期刊《细胞》(Cell)上在线发表了题为“A single-cell atlas reveals immune heterogeneity in ...

Generating a complete multimodal cell census and atlas of the mouse brain through collaborative data collection, tool development and analysis. This atlas combines single-cell transcriptomic ...

为解析屏状核（claustrum）的分子和细胞组织，研究人员开展了猕猴屏状核单细胞空间转录组图谱和全脑连接的研究。他们鉴定出 48 种细胞类型，明确了屏状核区域连接特点。该研究为阐释屏状核功能的神经元组织机制提供了依据。

A longitudinal atlas of neuroblastoma, a common and deadly childhood cancer, could uncover the precise molecular mechanisms ...

Researchers at Children's Hospital of Philadelphia (CHOP) developed a longitudinal atlas of neuroblastoma, a common and potentially deadly childhood cancer, to gain a deeper understanding into precise ...

The study is useful for advancing spatial transcriptomics through its novel regression-based linear model (glmSMA) that integrates single-cell RNA-seq with spatial reference atlases, though its ...