Na v 1.7 sodium channels are not present in cardiac muscle or CNS neurons, and this fact might be exploited to minimize adverse effects of sodium channel blockers. If these possibilities are ...

positively charged residues in an extracellular domain (S4) are important for channel gating. Sodium channels are important for generating electrical signals in neurons.

Four tiny 3D organs connected themselves in a lab dish, forming a replica of the human pain pathway, in a new study. The discovery allows scientists to better understand chronic pain and how pain ...

Stanford Medicine investigators have replicated, in a lab dish, one of humans' most prominent nervous pathways for sensing ...

1 Neurons are composed of a cell body containing the nucleus ... When the neuron is triggered, it activates voltage-gated sodium channels at the beginning of the axon. This causes an influx of ...

In neurons, the signal is in the form of a wave of opening and closing channels that exchange charged particles such as ...

This important computational study investigates homeostatic plasticity mechanisms that neurons may employ to achieve and maintain stable target activity patterns. The work extends previous analyses of ...