Although the technique reliably produces iPSCs, cellular reprogramming with the four Yamanaka factors—Oct4, Sox2, Klf4, and cMyc (collectively known as OSKM)—remains inefficient and incomplete, and it ...

This manuscript demonstrates that Oct4 overexpression synergizes with Notch inhibition (Rbpj knockout) to promote the conversion of adult murine Müller glia (MG) into bipolar cells. These findings are ...

The protocol relies on overexpressing the so-called Yamanaka factors, which are four transcription factors: Oct4, Sox2, Klf4, and cMyc (OSKM). While the technique reliably creates iPS cells, it can ...

The specialized cells in your liver, skin, and brain all first started from a stem cell. In animals, this process is ...