The second act of a popular reprogramming factor could maximize the potential of iPSCs in research and regenerative medicine.

The protocol relies on overexpressing the so-called Yamanaka factors, which are four transcription factors: Oct4, Sox2, Klf4, and cMyc (OSKM). While the technique reliably creates iPS cells, it can ...

These cells, created by reprogramming differentiated cells, rely on a cocktail of factors, including Sox2 and Oct4, to regain their pluripotent state. Research has long held that Sox and POU ...