One of the most amazing things to happen in biology in the last couple of years is cellular reprogramming. We learned how to ...

The second act of a popular reprogramming factor could maximize the potential of iPSCs in research and regenerative medicine.

The protocol relies on overexpressing the so-called Yamanaka factors, which are four transcription factors: Oct4, Sox2, Klf4, and cMyc (OSKM). While the technique reliably creates iPS cells, it can ...

These cells, created by reprogramming differentiated cells, rely on a cocktail of factors, including Sox2 and Oct4, to regain their pluripotent state. Research has long held that Sox and POU ...

This review highlights the critical role of ubiquitination in governing the functionality of cancer stem cells (CSCs), shedding light on potential therapeutic targets for combating tumor progression, ...

We can also provide OCT4 and SOX2 reporter hiPSC lines. Follow this procedure: We offer non-integrative (Sendai virus and episomal vector) technologies for reprogramming somatic cells. The standard ...