The DNA repair and replication pathways converge on a common final step in which the continuity of the repaired DNA strand is restored by DNA ligase, an enzyme that converts nicks into phosphodiester ...

The paper outlines a four-step process that removes RNF168 from ... proteins from reaching the damaged site. As a result, DNA repair fails. The significance of this research comes from the way ...

Advances in understanding DNA repair will be an important step to developing new therapies and healthcare strategies. “The ultimate challenge will be to get ever closer to watching how proteins ...

New structural findings on APE1–DNA cocrystals provide insights ... it coordinates potentially dangerous steps in the base excision repair pathway. Figure 1: Schematic representation of single ...

The discovery of the twisting switch resolves a long-standing question about how the DNA repair protein RNF168, which has a tendency to cause uncontrolled signalling, is switched off. The paper ...

Structure Maintenance of Chromosome (SMC) complexes are central to chromosome segregation, compaction and DNA repair, thereby impacting on gene expression and regulation. SMC family members that ...

PRRDetect is a new algorithm that identifies tumors with faulty DNA repair, helping doctors tailor cancer treatments more ...

Explore the latest findings on genetic networks and their role in DNA repair, opening new avenues for cancer therapies.