However, the intricate mechanisms governing these processes have remained elusive due to the presence of multiple functional domains within Munc13, each playing distinct roles in neurotransmitter ...

By immunofluorescence microscopy, neuroligin induced accumulation of the characteristic synaptic vesicle proteins synapsin, synaptotagmin and synaptophysin, as well as the synaptic scaffolding ...

It reveals a pore complex with extended arms that could bind receptors involved in synaptic vesicle exocytosis. Perhaps these multiple actions are needed to cover the diversity of targets ...

They did this at low and neutral pH values, such as those found in the so-called synaptic vesicle. After the toxin docks onto the receptor, this vesicle-like cell organelle takes up the toxin and ...

degeneration of dopaminergic neurons and dysregulated vesicle exocytosis of α-synuclein, and/or through disrupted synaptic vesicle transport via clathrin-mediated endo- and exocytosis.

Between impulses the transmitter molecules are rapidly removed from the synaptic cleft to prevent ... the presynaptic neuron and restored inside a vesicle ready to be used again.