A new study reveals how restoring α-synuclein levels can help preserve synaptic vesicle composition and function, offering therapeutic insights for Parkinson’s and other neurodegenerative diseases.

which are accumulated inside the vesicles—they do not really measure synaptic transmission. The groups decided to create an FFN that targeted the neuronal vesicular monoamine transporter (VMAT ...

(3) This causes synaptic vesicles to fuse with the terminal membrane, releasing neurotransmitter into the gap between neurons, known as the synaptic cleft. (4) The neurotransmitters bind to ...

Between impulses the transmitter molecules are rapidly removed from the synaptic cleft to prevent ... the presynaptic neuron and restored inside a vesicle ready to be used again.