By influencing calcium homeostasis, local protein synthesis and the endoplasmic reticulum, a small protein called Rab10 emerges as a crucial cytoplasmic regulator of neuropeptide secretion.

First discovered as proteins found on synaptic vesicles and at the presynaptic plasma membrane, SNAREs are members of a family of highly conserved proteins that reside on vesicles (v-SNAREs ...

A new study from Auburn University provides new insights into neuronal connections, offering hope for the treatment of ...

Clathrin-mediated endocytosis (CME) plays a crucial role in synaptic vesicle trafficking, and it has been hypothesized that CME impairment contributes to neuropathology related to schizophrenia.

We also found that the organization of the presynaptic milieu, including both synaptic vesicle pools and active zone scaffolding complexes, is fluid in nature, and dynamic liquid condensates are ...

Between impulses the transmitter molecules are rapidly removed from the synaptic cleft to prevent ... the presynaptic neuron and restored inside a vesicle ready to be used again.