▎药明康德内容团队编辑（来源：北京大学）神经传递是大脑信息交流的基础，其过程主要依赖于两种类型的囊泡：含有神经肽的大致密核心囊泡（Large dense core vesicle，LDCV）和含有小分子神经递质的突触小囊泡（Synaptic ...

在一项新的研究中，德国马克斯-德布吕克分子医学中心原位结构生物学实验室组长Misha Kudryashev教授及其同事们揭示了突触小泡（synaptic vesicle ...

Synaptic vesicle docking and fusion are mediated by the assembly of a stable SNARE core complex of proteins, which include the synaptic vesicle membrane protein VAMP/synaptobrevin and the ...

近期， 中国科学院 生物与化学交叉研究中心刘聪课题组和美国辛辛那提大学医学院刁佳杰课题组在 eLife 上合作发表了一篇题为 “N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine” 的研究论文 ...

Using cryo-electron tomography, the team was able to visualize synaptic vesicles (SVs) in 3D and confirm a potentially important protein-protein interaction. They also broadened our understanding ...

They also broadened our understanding of SV function and of how the vesicles are recycled. The study was published in the Proceedings of the National Academy of Sciences (PNAS.) “Synaptic ...

To do this, the synaptic vesicle must dock at the membrane of the presynaptic neuron and dump its content into the synapse, where it moves to particular receptors on the postsynaptic neuron.

The functioning of human cells resembles the way a city relies on a precise transport system to deliver various things and ...

Between impulses the transmitter molecules are rapidly removed from the synaptic cleft to prevent ... the presynaptic neuron and restored inside a vesicle ready to be used again.