SLE的临床表现具有高度异质性，系统受累表现多样：全身症状包括发热，疲乏和体重下降；典型的狼疮皮肤损害表现为面颊部蝶形红斑；典型的关节受累表现为对称分布的非侵蚀性关节痛和关节炎；肺最常见症状为胸膜炎；心脏受累表现为心包炎等；狼疮肾炎是SLE患者预后不良的主要危险因素。

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